EFFECT OF POLYCAPROLACTONE ON CHARACTERISTICS AND MORPHOLOGY OF ALGINATE/CHITOSAN/LOVASTATINE COMPOSITE FILMS

Nguyễn Thúy Chinh, Hoang Thai, Loc Thi Thach, Giang Duc Le, Thuy Phuong Ngo

Abstract


In this work, alginate (AG)/chitosan (CS)/lovastatine (LS) AG/CS/PCL/LS composite films using polycaprolactone (PCL)  are prepared by solution method with the ratio of AG/CS and LS content fixed at 4/1 and 10 wt.% (in comparison with the total weight of CS and AG), respectively.  The PCL content is used at 3, 5 and 10 wt.% (in compared with total weight of AG, CS and LS). The role of PCL as a compatibilizer in AG)/CS)/LS composites is considered by Fourier Transform Infrared Spectroscopy (FT-IR), Scanning Electron Microscopy (SEM) and Differential Scanning Calorimetric (DSC) methods. Based on the change in FTIR spectra, morphology and thermal parameters of AG/CS/PCL/LS composites, it can be seen that PCL has effectiveness of compatibility for AG, CS, and LS as well as plasticity for the composites. Besides, the influence of PCL content on the swelling degree of the composites is also investigated. 


Keywords


compatibility, polycaprolactone, lovastatine, alginate, solution method

Full Text:

PDF

References


Esmaeilzadeh J., Hesaraki S., Mehdi Hadavi S. M., Esfandeh M., Hosein Ebrahimzadeh M. - Microstructure and mechanical properties of biodegradable poly (D/L) lactic acid/polycaprolactone blends processed from the solvent-evaporation technique. Materials Science and Engineering C 71 (2017) 807–819

Di H., Tian-jiao W., Ge H., Yi-yi D., Yang D., Qin Z., Qiang F. - Synthesis of Janus POSS star polymer and exploring its compatibilization behavior for PLLA/PCL polymer blends. Polymer 136 (2018) 84-91.

Kamolrat C., Siriwan P. - Poly(lactic acid)/Polycaprolactone blends compatibilized

with block copolymer. Energy Procedia 34 (2013) 542 – 548.

Chen C.C., Chueha J.Y., Tseng H., Huang H.M., Lee S.Y. - Preparation and characterization of biodegradable PLA polymeric blends. Biomaterials 24 (2003) 1167–1173.

Semba T., Kitagawa K., Ishiaku U.S., Hamada H. - The effect of crosslinking on the mechanical properties of polylactic acid/polycaprolactone blends. J. Appl. Polym. Sci. 101 (2006) 1816–1825.

Ortega-Toro R., Munoz A., Talens P., Chiralt A. - Improvement of properties of glycerol plasticized starch films by blending with a low ratio of polycaprolactone and/or polyethylene glycol. Food Hydrocolloids 56 (2016) 9-19.

Trang N.T.T, Chinh N.T, Thanh D.T.M, Hang T.T.X, Giang N.V., Hoang T., Quan P.M., Giang L.D., Thai N.V., and Lawrence G. - Investigating the properties and hydrolysis ability of poly-lactic acid/chitosan nanocomposites using polycaprolactone. Journal of Nanoscience and Nanotechnology 15 (12) (2015) 9585– 9590

Chinh N.T., Ly N.T.H, Mai T.T., Trang N.T.T., Loc T.T., Giang L.D., Tung N.Q, Hoang T. - Characteristic and properties of chitosan/alginate polymer blend carrying lovastatin drug. Journal of Science and Technology 54 (2B) (2016) 118-124.

Cui-Yun Y., Xi-Chen Z., Fang-Zhou Z., Xian-Zheng Z., Si-Xue C., Ren-Xi Z. - Sustained release of antineoplastic drugs from chitosan-reinforced alginate microparticle drug delivery systems. International Journal of Pharmaceutics 357 (2008) 15-21.

Loreana L., Alexandre L.P., Valfredo F., Mauro C.M.L, Hellen K.S. - Development and evaluation of pH-sensitive sodium alginate/chitosan microparticles containing the antituberculosis drug rifampicin. Materials Science and Engineering C 39 (2014) 161–167.

Mohy Eldin M.S., Omer A.M., Wassel M.A., Tamer T.M., Abd Elmonem M.S., Ibrahim S.A. - Oval smart pH sensitive chitosan grafted alginate hydrogel microcapsules for oral protein delivery: I. preparation and characterization. International Journal of Pharmacy and Pharmaceutical Sciences 7 (10) (2015) 331-337.




DOI: https://doi.org/10.15625/2525-2518/56/4A/12738

Refbacks

  • There are currently no refbacks.


Index: Google Scholar; Crossref; VCGate; Asean Citation Index

Published by Vietnam Academy of Science and Technology