THE PROTECTIVE EFFECT OF SOME FRACTIONS AND ISOLATED COMPOUNDS FROM EUPHORBIA HIRTA L. ON PANCREATIC β-CELLS MIN6

Bach Thi Le, Dung Tien Le, Tuan Trong Nguyen, Thanh Quoc Chau Nguyen, Leclercq Joëlle Quetin, Buu Hue Thi Bui

Abstract


Euphorbia hirta L., a kind of herbs belonging to family Euphorbiaceae, has been found a lot in the Mekong Delta. From the ethyl acetat and methanol fractions of this plant, four pure compounds were isolated and identified their chemical structure by spectroscopic techniques including quercitrin (1), luteolin (2), quercetin (3) and caffeic acid (4). The effect of crude ethanolic extract and some fractioned extracts as well as four isolated compounds from E  hirta L., collected in the Mekong Delta, on endoplasmic reticulum stress-induced cell death in mouse β-cell lines was investigated. The results showed that methanol fraction and a isolated compound, quercitrin gave strong cell-protective effect with the cell viability of 69% and 78% at the dose of 100 µg/mL and 10 µg/mL, respectively. This proves that E hirta L. might have anti-diabetic effects and worth conducting further pharmacological investigations related to type 2 diabetes mellitus.

 


Keywords


Euphorbia hirta L., ER Stress, MIN6.

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References


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DOI: https://doi.org/10.15625/2525-2518/56/4A/12753

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