TRITERPENES FROM DOCYNIA INDICA FRUITS AND THEIR CYTOTOXIC ACTIVITY

Lê Xuân Duy

Abstract


Five triterpenes were isolated from the ethyl acetate fraction of methanolic extract of Docynia indica fruits. Their structures were determined to be pomolic acid (1), maslinic acid (2), ursolic acid (3), 23-hydroxy ursolic acid (4) and euscaphic acid (5) by comparison of physicochemical, NMR and mass spectral data with those reported in the literature. All triterpenes (15) were isolated for the first time from Docynia indica. Compounds 15 were evaluated for their cytotoxic activity using MTT assay, of which 23-hydroxy ursolic acid (3) and ursolic acid (4) showed cytotoxic activities against HeLa and Hep-G2 cancer cell lines.

 


Keywords


Docinya indica; Rosaceae; triterpenes; HeLa and Hep-G2 cancer cell lines

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DOI: https://doi.org/10.15625/2525-2518/56/4A/12982

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Published by Vietnam Academy of Science and Technology