Nguyen Thi Kim An, Ngo Dai Quang, Pham Quoc Long, Tran Thi Thu Thuy


Five prenylated caged xanthones, desoxymorellin, morellic acid, gambogic acid, isogambogic acid and 10α-butoxy gambogic acid , were isolated from the stem bark of Garcinia hanburyi collected in Vietnam. Their structures were elucidated by detailed 1D, 2D NMR spectroscopic analyses and comparison with reported data. Two major constituents, gambogic acid and isogambogic acid, displayed strong cytotoxicity against LLC and SK-LU-1cell lines with IC50 values in the range from 0.35±0.05 µM to 2.26±0.19 µM. This is the first study on the cytotoxicity of gambogic acid and isogambogic acid against LLC and SK-LU-1 lung cancer cell lines.


prenylated caged xanthones, Garcinia hanburyi, gambogic acid, cytotoxicity, LLC and SK-LU-1

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Ravichandran S., Chen B., Cai X., Fu R. - Anticancer and multidrug-resistance reversing potential of traditional medicinal plants and their bioactive compounds in leukemia cell lines, Chin. J. Nat. Med. 12 (2014) 881–894.

Yaowapa S., Vatcharin R., Souwalak P. - Antibacterial caged-tetraprenylated xanthones from the fruits of Garcinia hanburyi, Chem. Pharm. Bull. 53 (2005) 850–852.

Asano J., Chiba K., Tada M., Yoshi T., Souwalak P. - Cytotoxic xanthones from Garcinia

hanburyi, Phytochemistry 41 (1996) 815–820.

Deng X. Y., Pan S. L., Zhao S. Y., Wu M. Q., Sun Z. Q., Chen X. H., et al., Cytotoxic

alkoxylated xanthones from the resin of Garcinia hanburyi, Fitoterapia 83 (2012) 1548–1552.

Han Q. B., Wang Y. L., Yang L., Tso T. F., Qiao C. F., Song J. Z., et al. - Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi, Chem. Pharm. Bull. 54 (2006) 265–267.

Han Q. B., Yang L., Wang Y. L., Qiao C. F., Song J. Z., Sun H. D., et al. - A pair of novel cytotoxic polyprenylated xanthone epimers from gamboges, Chem. Biodivers. 3 (2006) 101–105.

Tao S. J., Guan S. H., Wang W., Lu Z. Q., Chen G. T., Sha N., et al. - Cytotoxic polyprenylated xanthones from the resin of Garcinia hanburyi, J. Nat. Prod. 72 (2009) 117–124.

Wang L. L., Li Z. L., Xu P. Y., Liu X. Q., Pei Y. H., Jing Y. K., et al. - A new cytotoxic caged polyprenylated xanthone from the resin of Garcinia hanburyi, Chin. Chem. Lett. 19 (2008) 1221–1223.

Ren Y. L., Yuan C. H., Chai H. B., Ding Y. Q., Li X. C., Daneel F., et al. - Absolute configuration of (-)-gambogic acid, an antitumor agent, J. Nat. Prod. 74 (2011) 460–463.

Tao S. J., Guan S. H., Li X. G., Guo D. A. - A highly rearranged pentaprenylxanthonoid from the resin of Garcinia hanburyi, Helv. Chim. Acta. 93 (2010) 1395–1400.

Wang X. J., Lu N., Yang Q., Dai Q. S., Tao L., Guo X. K., et al. - Spectacular modification of Gambogic acid on microwave irradiation in methanol: isolation and structure identification of two products with potent anti-tumor activity, Bioorg. Med. Chem. Lett. 20 (2010) 2438–2442.

Anantachoke N., Tuchinda P., Kuhakarn C., Pohmakotr M., Reutrakul V. - Prenylated caged xanthones: chemistry and biology, Pharm. Biol. 50 (2012) 78–91.

Monks A., Scudiero D., Skehan P., Shoemaker R., Paull K., Vistica D., Hose C., Langley J., Cronise P., Vaigro-Wolff A., Gray-Goodrich M. - Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. Journal of the National Cancer Institute 83 (11) (1991) 757-766.

Nguyen H. D., Trinh B. T. D., Nguyen L. H. D. - Guttiferones Q-S, cytotoxic polyisoprenylated benzophenones from the pericarp of Garcinia cochinchinensis, Phytochem. Lett. 4 (2011) 129-133.

Chien S. C., Chyu C. F, Chang I. S., Chiu H. L., Kuo Y. H. - A novel polyprenylated phloroglucinol, garcinialone, from the roots of Garcinia multiflora, Tetrahedron Lett. 49 (2008) 5276-5278.

Han Q. B., Yang N. Y., Tian H. L., Qiao C. F., Song J. Z., Chang D. C., Chen S. L., Luo K. Q., Xu H. X. - Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis, Phytochem. 69 (2008) 2187-2192.

Nguyen L. H. D., Vo H. T., Pham H. D., Connolly J. D., Harrison L. J. - Xanthones from the bark of Garcinia merguensis, Phytochem. 63 (2003) 467-470.

Nguyen L. H. D., Harrison L. J. - Xanthones and triterpenoids from the bark of Garcinia vilersiana, Phytochem. 53 (2000) 111-114.

Bhat H. B., Nair P. M., Venkataraman K. The colouring matters of G. morrella, Part V. Isolation of deoxymorellin and dihydroisomorellin, Indian J. Chem. 2 (1964) 405-410.

Karanjgaonkar C. G.., Nair P. M., Venkataraman K. - Morellic, isomorellic and gambogic acidsa, b, Tetrahedron Let. 7 (1966) 687-691.

Nguyen T. K. A., Ngo D. Q., Pham Q. L., Tran T. T. T. - Polyprenylated caged xanthones from the resin of Garcinia hanburyi growing in Vietnam, J. Chem. (2019) in press.

Lin L. J., Lin L. Z., Pezzuto J. M., Cordell G. A. - Isogambogic acid and isomorellinol from Garcinia hanburyi, Magnetic resonance in chemistry 31 (1993) 340-347.

Chen Y., He S., Chu Tang C., Li J., Yang G. - Caged polyprenylated xanthones from the resin of Garcinia hanburyi, Fitoterapia 109 (2016) 106-112.

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