NEW QUINAZOLINONE DERIVATIVES: SYTHESIS AND IN VITRO CYTOTOXIC ACTIVITY

tran khac vu

Abstract


The paper presents a simple synthesis of new quinazolinone derivatives 13a-i. Synthesized derivatives were tested for their cytotoxic effect against three cancer cell lines including SKLU-1, MCF-7 and HepG-2. The bioassay result showed that only compound 13e exhibited significant cytotoxic effect against cancer cell lines tested with IC50 values of 9.48, 20.39 and 18.04 µg/ mL, respectively.


Keywords


6-Hydroxy-4(3H) quinazolinone, cytotoxic, cancer

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DOI: https://doi.org/10.15625/2525-2518/58/1/14391 Display counter: Abstract : 38 views. PDF : 0 views.

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