PTP1B INHIBITORS FROM ISODON TERNIFOLIUS COLLECTED IN VIETNAM

Nguyen Phi-Hung

Abstract


From the whole plant of Isodon ternifolius collected in Vietnam, four triterpens including ursaldehyde (1), ursolic acid (2), b-sitosterol (3) and b-sitosteryl ferulate (4) were purified. Their chemical structures were determined by interpretation of NMR and MS data and comparison with the literatures. Compounds 1-4 were evaluated for their inhibitory activity against PTP1B enzyme activity using in vitro assay. Compounds 1 and 2 displayed potential activities with IC50 values of 16.92 ± 0.12 and 3.42 ± 0.45 μM, respectively. This is the first time that compounds 1 and 4 have been isolated from the Isodon genus and I. ternifolius has been evaluated for the PTP1B inhibitory activity.

Keywords


Isodon ternifolius, Lamiaceae, whole plant, ursane-type triterpene, sterol, PTP1B

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References


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DOI: https://doi.org/10.15625/2525-2518/58/5/15012 Display counter: Abstract : 70 views. PDF : 6 views.

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