Platelet rich fibrin stimulate the proliferation of human periodontal ligament stem cells

Trinh Ngoc Le Van, Nguyen Thi Thu Ha, Nguyen Thu Thao, Pham Anh Vu Thuy, Tran Le Bao Ha


Platelet rich fibrin (PRF), a gel formed during coagulation from fibrin fibers and a large amount of activated platelets, is considered a potential biomaterial for periodontal disease treatment. The fibrin fiber network, acting as a mesothelial barrier, along with growth factors released by platelets, can inhibit inflammation and support tissue regeneration. In this study, whole blood samples were collected without anticoagulants and immediately centrifuged at 2500 rpm for 15 mins to prepare PRF. From 5 ml of whole blood, the procedure can produce a PRF volume of 1.83 ± 0.15 ml. The PRF produced was shown to have the fibrin fiber network with platelet concentration 2.74 ± 0.22 times higher than in normal state blood. In addition, PRF extract can stimulate the proliferation and migration of human periodontal ligament stem cells. This study demonstrated the potential application of PRF to periodontal disease treatment in particular and implants in general.


Mesothelial barrier, periodontal disease treatment, periodontal ligament stem cells, platelet rich fibrin, proliferation.

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