Evaluation and application of Drosophila melanogaster model for anti-cancer herb screening

Vu Hoang Giang, Cao Thi Thuy Trang, Nguyen Minh Can, Dang Ngoc Anh Suong, Dang Thi Phuong Thao

Abstract


In this study, we evaluate Drosophila melanogaster model which over-express YorkieS168A protein in order to apply the model for anti-cancer herb screening. Transcriptional co-activator YorkieS168A (Yki) plays a role in organ size control and concerns some cancer diseases. In fly model, over-expression of YorkieS168A protein at eye tissue causes abnormal eye phenotype. As mass of cancerous cells, the abnormal eye phenotype is resulted by miss-control of cell proliferation as shown by anti PH3 signal after morphogenesis furrow. Interestingly, our results also show that ethanol 50% extraction of Ehretia asperula Zoll. & Mor. reduces abnormal eye phenotype in over-expressed YkiS168A flies. All the results show that over-expressed YkiS168A fly model serves as a potential model for anti-cancer herb screening.


Keywords


Drosophila melanogaster, Ehretia asperula, anti-cancer, transcription factor yorkie

Full Text:

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DOI: https://doi.org/10.15625/0866-7160/v37n1se.6117 Display counter: Abstract : 56 views. Untitled : 227 views.

 

                 

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