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Tổng hợp 21-acetat pregn-4,9(11)-dien-17α,21-diol-3,20-dion

Lưu Đức Huy, Nguyễn Thị Diệp, Phạm Thị Thảo, Lưu Đức Hùng

Abstract


In this paper, we present the synthesis of the 21-acetate pregna-4,9(11)-diene-17α,21-diol-3,20-dione from 9α- hydroxy androstenedione, an important intermediate for synthesis of corticoids such as hydrocortisone and prednisolone. The structure of the product and its intermediates was examined by physical methods such as: IR, MS, 1H and 13C NMR.

Keywords: 21-acetate pregna-4,9(11)-diene-17α,21-diol-3,20-dione, 9α-hydroxy androstenedione.


Keywords


21-acetate pregna-4,9(11)-diene-17α,21-diol-3,20-dione, 9α-hydroxy androstenedione

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