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Study on transformation of zerumbone with fatty acid hydrazides

Vuong Van Truong, Pham Duy Nam, Nguyen Dinh Thanh, Van Ngoc Huong, Trinh Thi Thuy Lien, Luu Van Chinh


Zerumbone was isolated from several plant species of the Zingiberaceae family that have shown many potential biological activities, such as antiproliferative, antioxidative, anti-inflammatory, and anticancer activities. Due to these biological effects, many scientists have tried to synthesize zerumbone derivatives and evaluate their bioactivities. In this paper, we report the synthesis of nine new zerumbone derivatives by the condensation of zerumbone and zerumbone oxide with fatty acid hydrazides. The structure of these compounds has been confirmed by 1H NMR, 13C NMR and FT-ICR-MS spectroscopic data.



Zerumbone, zerumbone oxide, fatty acid hydrazide, condensation

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