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A new isomalabaricane from Vietnamese marine sponge Petrosia ingricans

Phan Van Kiem, Ngo Van Quang, Nguyen Xuan Nhiem, Dan Thi Thuy Hang, Hoang Le Tuan Anh, Pham Hai Yen, Duong Thi Dung, Nguyen Thi Cuc, Chau Van Minh, Nguyen Thi Mai Phuong


A new isomalabaricane triterpene, nigricanic acid A (1), and two known compounds (24S)-ergostane 3β,5α,6β,25-tetraol-25-monoacetate (2) and (24S)-ergostane-1β,3β,5α,6β,25-pentaol-25-monoacetate (3), was isolated from Vietnamese marine sponge Petrosia nigricans. Their structures were determined on the basis of 1D and 2D-NMR spectra and HR-ESI-MS, and in comparison with the reported data. The cytotoxicity of all compounds were evaluated by MTT assay on four human cancer cell lines, including Hep-G2, KB, LU-1, and MCF-7. As the results, compound 1 exhibited moderate cytotoxic activity on the four human cancer cell lines with IC50 values ranging of 15.47÷19.34 μg/mL.


Isomalabaricane, Petrosia nigricans

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