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Nghiên cứu tổng hợp chọn lọc 10β-Azidoartemisinin

Trần Khắc Vũ, Lê Huy Bình, Nguyễn Thanh Bình, Nguyễn Thị Thúy Vân

Abstract


This paper presents a simple method for selective synthesis of the key compound, 10β-azidoartemisinin. The compound 10β-azidoartemisinin was selectively synthesized by the reaction of dihydroartemisinin (2) with NaN3, KI using ZnCl2 as a catalyst at 0-5 oC. The structure of 10β-azidoartemisinin was elucidated based on 1H, 13CNMR spectrum and known documents.


Keywords


Artemisinin, dihydroartemisinin, artemether, arteether, sodium azide

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