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Thành phần hóa học và hoạt tính gây độc tế bào của loài kim giao núi đất (Nageia wallichiana) thu tại tỉnh Lâm Đồng. Phần 1. Các hợp chất diterpenoid.

Nguyễnq Thị Liễu, Phạm Thị Ninh, Nguyễn Thị Hoàng Anh, Trịnh Thị Thủy, Nguyễn Thị Lưu, Trần Văn Lộc, Đinh Thị Phòng, Trần Thị Phương Thảo, Trần Văn Sung

Abstract


From the ethyl acetate extract of Nageia wallichiana, collected in Lam Dong province, Vietnam four diterpenoids with the abietane skeleton and one nor-diterpene dilacton have been isolated. Their structures were elucidated by using combined spectroscopic methods as IR, MS and NMR. The cytotoxic activity of three of five compounds against 8 human cancer cell lines has been evaluated.  The nor-diterpene dilactone showed strong activity on all tested cancer cell lines. This is the first report on the chemical constituents and the cytotoxic activity of Nageia wallichiana.

Keywords. Diterpenoids, nor-diterpene dilactone Nageia wallichiana, cytotoxicity.

Keywords


Diterpenoids, nor-diterpene dilactone Nageia wallichiana, cytotoxicity.

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