Cyclopeptide alkaloid and lignans from Antidesma hainanensis Merr.

Le Canh Viet Cuong, Do Thi Trang, Nguyen Xuan Nhiem, Pham Hai Yen, Bui Huu Tai, Hoang Le Tuan Anh, Le Mai Huong, Chau Van Minh, Phan Van Kiem


Cyclopeptide alkaloid lotusanine B (1) and three lignans (-)-lyoniresinol (2), (+)-lyoniresinol 3α-O-β-D-glucopyranoside (3), and (+)-isolariciresinol 3α-O-β-D-glucopyranoside (4) were isolated from the methanol extract of the Antidesma hainanensis leaves. Their chemical structures were successfully determined using NMR and ESI-MS analysis as well as in comparison with the reported data. Especially, the NMR data of lotusanine B were first confirmed by 2D-NMR spectroscopies and reassigned. This is the first report of lotusanine B from Euphorbiaceae family.


Antidesma hainanensis, Euphorbiaceae, lotusanine B, lignan.

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