Bước đầu nghiên cứu tổng hợp mafenit axetat qua trung gian phtalimit

Nguyễn Văn Giang, Hoàng Xuân Nghĩa, Nguyễn Văn Hải, Nguyễn Đình Luyện


Currently, topical antibacterial creams based on mafenide acetate are among the most common medicines used for the treatment of burns against approximately all pathogens colonized in burn wounds, including Pseudomonas aeruginosa and Clostridia. In this paper, mafenide acetate has been successfully synthesized through phthalimide intermediate. The structure of the intermediate derivatives and mafenide acetate were confirmed by IR, 1H-NMR,      13C-NMR spectroscopy and ESI-MS.

Keywords. Mafenide acetate, burn, phthalimide, N-benzylphthalimide, chlorosulfonation.


Mafenide acetate, burn, phthalimide, N-benzylphthalimide, chlorosulfonation

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