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Synthesis of some α,β-unsaturated ketones from 3-acetyl-4-hydroxy-N-methyl quinonlin-2-one.

Nguyễn Minh Thảo, Vũ Thị Minh Thư, Trần Văn Sơn


The reaction of N-methylaniline with diethylmalonate has given 3-acetyl-4-hydroxy-N-methylquinolin-2-one, which in condensation with aromatic aldehydes has afforded new α, β-unsaturated ketones. Structure of these compounds has been confirmed by IR, 1H-NMR and MS spetroscopic data. Biological activities of α, β-unsaturated ketones have been investigated.


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