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NMR spectroscopy using a chiral lanthanide shift reagent to determine the enantiomeric purity of nicotine and the geometric parameters of lanthanide-nicotine complex.

Thanh Thi Thu Thuy, Thai Thuy Duong, Pham Ngoc Khanh, Dang Vu Luong, Nguyen Tien Tai

Abstract


In this paper, we reported a simple method for determining the enantiomeric purity of  nicotine extracted from tobacco leaves by 13C-NMR spectroscopy using a chiral shift reagent Ytterbium(III) tris[3-(trifluoropropylhydroxy-methylene)-l-camphorate] (Yb(tfc)3). The results showed that the studied native nicotine contained 98% S-Nicotine and 2% R-Nicotine. The geometric parameters of Yb(tfc)3-Nicotine complex were calculated by means of  well-known McConnell-Robertson equation.


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