Synthesis of new quinoline derivaties containing chalcone side chain

Le Thi Thuy, Dao Huy Toan, Hoang Xuan Tien, Tran Khac Vu


Novel chalcone-based quinoline derivatives (7a-c) were synthesized via a two-step procedure. In the first step, the reaction of 4-aminoacetophenone with different aldehydes in ethanol in the presence of NaOMe/MeOH afforded the corresponding chalcones (6a-c) in moderate to good yields. In the second step, the chalcones (6a-c) were respectively reacted with 4,7-dichloroquinoline in ethanol to obtain novel quinoline derivatives (7a-c)  in good to excellent yields. All synthesized compounds were structurally characterized by modern spectroscopic methods: IR, 1H and 13C NMR

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