Sesquiterpene phenols from marine sponge Smenospongia cerebriformis.

Le Thi Huyen, Dan Thi Thuy Hang, Nguyen Xuan Nhiem, Bui Huu Tai, Hoang Le Tuan Anh, Pham Hai Yen, Nguyen Van Dau, Chau Van Minh, Phan Van Kiem


Using various chromatography methods, four sesquiterpene phenols, dictyoceratin C (1), polyfibrospongol A (2), polyfibrospongol B (3), and 19-hydroxy-polyfibrospongol B (4) were isolated from the methanol extract of the Vietnamese marine sponge Smenospongia cerebriformis. Their structures were determined by 1D-, 2D-NMR spectra, HR-ESI-MS and in comparison with those reported in the literature.

Keywords. Smenospongia cerebriformis, sponge, sesquiterpene phenol.


Smenospongia cerebriformis, sponge, sesquiterpene phenol.

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Park S. et al. Ilimaquinone and ethylsmenoquinone, marine sponge metabolites, suppress the proliferation of multiple myeloma cells by down-regulating the level of β-catenin, Mar. Drugs, 12(6), 3231-3244 (2014).

Kochanowska A. J. et al. Secondary Metabolites from Three Florida Sponges with Antidepressant Activity, J. Nat. Prod., 71(2), 186-189 (2008).

Dai J. et al. Dictazoles: Potential Vinyl Cyclobutane Biosynthetic Precursors to the Dictazolines, J. Org. Chem., 75(7), 2399-2402 (2010).

Dai J. et al. Dictazolines A and B, Bisspiroimidazolidinones from the Marine Sponge Smenospongia cerebriformis, J. Nat. Prod., 71(7), 1287-1290 (2008).

Hwang I. H. et al. A novel natural phenyl alkene with cytotoxic activity, Tetrahedron Lett., 54(29), 3872-3876 (2013).

Shugeng C. et al. Marine Sesquiterpenoids that Inhibit the Lyase Activity of DNA Polymerase b. Journal of Natural Products, 67, 1716-1718 (2004).

Shen Y. C. and P. W. Hsieh. New Sesquiterpene Hydroquinones from a Taiwanese Marine sponge Polyfibrospongia australis, Journal of Natural Products, 60, 93-97 (1997).

Yan Q. and M. W. Xiu. A New Sesquiterpenoid Hydroquinone from the Marine Sponge Dysidea arenaria, Molecules, 13, 1275-1281 (2008).

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