Lignans isolated from the ethyl acetate extract of Knema pachycarpa fruit

To Hai Tung, Cao Thi Hue, Tran Huu Giap, Ha Thi Thoa, Nguyen Anh Dung, Nguyen Thi Minh Hang, Nguyen Van Hung, Le Nguyen Thanh


Knema is a genus of tropical evergreen trees of the family Myristicaceae found in South East Asian countries such as Vietnam, Thailand, and Malaysia. In this paper, four lignans, (+)-pinoresinol (1),(+) epi-pinoresinol (2), piperitol (3), and pluviatilol (4), were isolated from the ethyl acetate extract of the fruit of Knema pachycarpa, an indigenus tree in Vietnam. The chemical structures were determined by spectroscopic data and comparison with the reported literature. These compounds were isolated from Knema genus for the first time.

Keywords. Knema pachycarpa de Wilde, (+)-Pinoresinol, (+)-Epi-pinoresinol, Piperitol, Pluviatilol.


Knema pachycarpa de Wilde, (+)-Pinoresinol, (+)-Epi-pinoresinol, Piperitol, Pluviatilol

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Pham Hoang Ho. An illustrated flora of Vietnam. 282-285, Youth Publisher (1999).

M. N. Akhtar, K. W. Lam, F. Abas, Maulidiani, A. Ahmad, S. A. A. Shah, Atta-ur-Rahman, M. I. Choudhary, N. H. Lajis. New class of acetylcholinesterase inhibitors from the stem bark of Knema laurina and their structural insights. Bioorg. Med. Chem. Lett., 21, 4097-4103 (2011).

N. Rangkaew, R. Suttisri, M. Moriyasu, K. Kawanishi. A new acyclic diterpene and bioactive compounds from Knema glauca, Arch. Pharm. Res., 32, 685-692 (2009).

M. J. T. G. Gonzalez, M. M. M.Pinto, A. Kijjoa, C. Anantachoke, W. Herz. Stilbenes and other constituents of Knema austrosiamensis.

Phytochemistry, 32, 433-438 (1993).

H. P. Ji, W. Y. Seung, G. C. Jin, Y. L. Dae, S. K. Yong, and I. B. Nam. Lignans from silkworm droppings and their promotional activities on heme oxygenase-1 (HO-1), J. Korean Soc. Appl. Biol. Chem., 53(6), 734-739 (2010).

A. S. Nigel, C. D. B. Richard and B. Gordon. A versatile stereoselective synthesis of endo,exo-furofuranones: Application to the enantioselective synthesis of furofuran lignans, J. Org. Chem., 69, 122-129 (2004).

Fumiko, Y. Shoji, K. Kimiko, N. Genichiro, O. Hikaru, N. Istuo. Studies on Xanthoxylum spp. II. Constituents of the bark of Xanthoxylum piperitum DC., Chem. Pharm. Bull., 22, 2650-2655 (1974).

T. Hitoshi, N. Takeshi, I. Kazuhiko, and I. Kazuo. A lignan from Actinodaphne longifolia, Phytochemistry, 28(3), 952-954 (1989).

S. Z. Choi, M. C. Yang, S. U. Choi and K. R. Lee. Cytotoxic terpenes and lignans from the roots of Ainsliaea acerifolia, Arch. Pham. Res., 29(3), 203-208 (2006).

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