Nghiên cứu cấu trúc của fucoidan có hoạt tính gây độc tế bào tách từ rong nâu Sargassum swartzii bằng phương pháp phổ khối nhiều lần

Nguyễn Duy Nhứt, Bùi Minh Lý, Thành Thị Thu Thuỷ, Nguyễn Mạnh Cường, Trần Văn Sung

Abstract


We reported a study of the structure of cytotoxic fucoidan fraction extracted from brown seaweed Sargassum swartzii by using NMR and tandem mass spectrometry in combination with a Pascal software program. Fucoidan F-20 is composed mainly of fucose, accompanied by other monosaccharids (mostly Gal, but also Glc, Rha and Xyl), and significant amount of uronic acids and sulfate. MS/MS analysis showed the cytotoxic fucoidan F-20 has linear sequences of hexose-disulfated fucose-sulfated fucose-hexose. The fucoidan structure is chracterized by the branch of two glucuronic acid units linked to the hexose unit and fucose to the sulfated fucose.

 


Keywords


Sargassum swartzii, sulfated fucoidan, tandem mass spectrometry, cytotoxic.

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