Tổng hợp một số dẫn xuất của cycloart-23Z-ene-3beta-25-diol và hoạt tính sinh học của chúng

Nguyễn Văn Tuyến, Nguyễn Văn Hùng, Nguyễn Quyết Chiến


Cycloart-23Z-ene-3β-25-diol was  isolated from the leaves of Aglaia gigantea by bioassay-guided fractionation. This compound showed very good cytotoxicity against human hepatoma  (Hep-G2) and KB cells. In oder to investigate the relationship between biological activity and structure of the derivatives of cycloart-23Z-ene-3β-25-diol, we carried out synthesis of several new  derivatives and examined their biological activities.

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