Nghiên cứu tổng hợp và chuyển hóa 6-axetyl-5-hidroxi-4-metylcumarin và 6-axetyl-7- hidroxi-4-metylcumarin

Nguyễn Minh Thảo, Nguyễn Văn Vinh, Trần Quốc Toản, Nguyễn Đức Chỉnh


By the acetylation of resorcinol by  acetic acid and ZnCl2 has been obtained  2,4-dihydroxyacetophenone, which in reaction with ethyl acetoacetate to give 6-acetyl-5-hydroxy-4-methylcoumarine or 6-acetyl-7-hydroxy-4-methylcoumarine. By condensation of 6-acetylcoumarines derivatives with aromatic aldehydes have been prepared the series of α,β-unsaturated ketones. Antimicrobial and antifungal activities of these compounds have been investigated. Structure of these products have been determined by IR, 1H-NMR and MS spectroscopies.

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