Dipeptide and phenolic compounds from the leaves of Cudrania tricuspidata Carr. Bur and their cytotoxic activity

Hoang Le Tuan Anh, Do Thi Trang, Do Thanh Tuan, Tran Minh Duc, Tran Thi Phuong Anh, Duong Thi Hai Yen, Nguyen Xuan Nhiem, Chau Van Minh, Bui Huu Tai, Phan Van Kiem


By various chromatographic separations, two peptides, aurantiamide acetate (1) and aurantiamide (2), and two phenolic compounds, (E)-p-coumaric acid (3) and gatrodin (4), were isolated from methanol extract of the Cudrania tricuspidata leaves. Their structures were determined by 1D-, 2D-NMR spectra and in comparison with the reported data. Aurantiamide exhibited significant cytotoxic activity on HL-60 leukemia human cancer cell line with IC50 value of 20.41 mM. Compounds 1 and 2 were reported from genus Cudrania for the first time.

Keywords. Cudrania tricuspidata, aurantiamide, aurantiamide acetate.


Cudrania tricuspidata, aurantiamide, aurantiamide acetate.

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