SEPARATION PROCESS OF ROSMARINIC ACID AND THEIR DERIVATIVES FROM CELASTRUS HINDSII BENTH LEAVES

Ly Ngoc Tram

Abstract


Rosmarinic acid is a naturally antioxidant, which is biosynthesized from the amino acids Lphenylalanine
and L-tyrosine by eight enzymes that include phenylalanine ammonia lyase and
cinnamic acid 4-hydroxylase. Rosmarinic acid can also be chemically produced by the
esterification of caffeic acid and 3,4-dihydroxyphenyllactic acid. Recently, rosmarinic acid and
its derivatives (RA) have attracted interests for their biological activities, which include antiinflammatory,
anti-oxidant, anti-angiogenic, anti-tumor, and anti-microbial functions. RA
extraction procedure from Xaden leaves Celastrus hindsii was investigated. RA extracts were
obtained from 50 % ethanol extract. The optimal conditions for extraction were as followings:
solvent/material ratio 12/1 (v/m), two time extractions, and total extraction time of 3 hours. RA
extracts were refined by Diaion HP-20column to have RA with 83.30 % purity and yield 2.86 %
(by dry weight material).


Keywords


Xaden, Celastrus hindsii Benth, rosmarinic acid.

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DOI: https://doi.org/10.15625/2525-2518/54/2C/11865 Display counter: Abstract : 240 views. PDF : 274 views.

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