SYNTHESIS AND CYTOTOXIC ACTIVITY EVALUATION OF NOVEL DERIVATIVES OF MURRAYAFOLINE A

Le Duc Anh

Abstract


Two new conjugates of murrayafoline A with zerumbone and artemisinin 3, 11 were
prepared by N-alkylation, in which, compound 3 was synthesized from two consecutive Nalkylation
reactions. Their cytotoxicity was evaluated on four human cancer cell lines Hep-G2,
LU, RD and Fl. The result showed that both compounds exhibited no activity against the tested
cell lines.


Keywords


murrayafoline A, N-alkylation, cytotoxicity, sesquiterpene, conjugate.

Full Text:

PDF


DOI: https://doi.org/10.15625/2525-2518/54/2C/11880 Display counter: Abstract : 189 views. PDF : 133 views.

Refbacks

  • There are currently no refbacks.


Bioteknologi Agrikultur

Index: Google Scholar; Crossref; VCGate; Asean Citation Index

Published by Vietnam Academy of Science and Technology