PTP1B INHIBITORY CONSISTUENTS FROM VIETNAMESE MEDICINAL PLANT SELAGINELLA TAMARISCINA

Nguyen Phi Hung

Abstract


Inhibitors of protein tyrosine phosphatase 1B (PTP1B) are promising agents for the
treatment of type 2 diabetes and obesity. From the alcoholic extract of the aerial parts of
Selaginella tamariscina, four compounds including selaginellin (1), amentoflavone (2), β-
sitosterol (3), and scoparone (4) have been isolated and structurally elucidated by using
combined chromatographic and spectroscopic experiments. Among the isolates, selaginellin (1)
and amentoflavone (2), exhibited potential PTP1B inhibitory activities with IC50 values of 15.9 ±
0.6 and 7.4 ± 0.5 μM, respectively.


Keywords


Selaginella tamariscina, PTP1B inhibitors, biflavonoids, selaginellins, Quyen ba.

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DOI: https://doi.org/10.15625/2525-2518/54/2C/11882 Display counter: Abstract : 153 views. PDF : 112 views.

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Published by Vietnam Academy of Science and Technology