Cytotoxicity of α-mangostin encapsulated polymeric nanoparticles against lung cancer cells

Authors

  • Nguyen Thi Mai Phuong Viện Công nghệ sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam Học Viện Khoa học và Công nghệ Việt Nam
  • Tran Dai Lam Học Viện Khoa học và Công nghệ Việt Nam
  • Ta Thu Mai Viện Công nghệ sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam
  • Nguyen Trung Hop Viện Công nghệ sinh học, Viện Hàn lâm Khoa học và Công nghệ Việt Nam

DOI:

https://doi.org/10.15625/0866-7160/v40n1.10504

Keywords:

Garcinia mangostana, alpha-mangostin, cancer cell lines, cytotoxicity, nanoparticles

Abstract

Alpha-Mangostin (AMG) isolated from Garcinia mangostana L., has been intensively reported to possess potent anti-cancer properties. However its clinical application is limited due to poor aqueous-solubility. Here, we successfully synthesised and characterised water-soluble ß-cyclodextrin-coated AMG (NMG) with size of <50 nm and zeta potential of -38 mV. The changes in spectra of NMG compared to NMG suggested an interaction between AMG and the carrier ß-cyclodextrin. Similar cytotoxic activities against lung cancer cells A549 of water-soluble NMG and organic-solvent soluble AMG were found with IC50 of 2.34 and 4.86 µg/ml, respectively. Moreover, observation under fluorescent microscopy indicated that NMG was taken up into the cancer cells and clearly affected nuclear morphology. The obtained data demonstrates that the synthesized NMG improves bioavailability of AMG while maintains its anti-cancer activity. Citation: Nguyen Thi Mai Phuong, Tran Dai Lam, Ta Thu Mai, Nguyen Trung Hop, 2018. Cytotoxicity of α-mangostin encapsulated polymeric nanoparticles against lung cancer cells. Tap chi Sinh hoc, 40(1): 108-114. DOI: 10.15625/0866-7160/v40n1.10504. *Corresponding author: phuongnguyenibt@gmail.com Received 7 November 2018, accepted 12 March 2018

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Published

16-04-2018

How to Cite

Mai Phuong, N. T., Lam, T. D., Mai, T. T., & Hop, N. T. (2018). Cytotoxicity of α-mangostin encapsulated polymeric nanoparticles against lung cancer cells. Academia Journal of Biology, 40(1), 108–114. https://doi.org/10.15625/0866-7160/v40n1.10504

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