Antioxidant activity and anti-hyperglycemic effect from <i> Adenosma bracteosum </i> Bonati
Keywords:Adenosma bracteosum, antioxidant activity, anti-hyperglycemic activity, CCl4, extracts.
Adenosma bracteosum (Bonati) has been used in traditional and folk medicine in Vietnam as a treatment for liver disease but there were few information about its characteristics of antibictie. The aim of the present study was to evaluate antioxidant activity and anti-hyperglycemic potential of extracts from A. bracteosum. Chloroform, ethanolic and aqueous A. bracteosum extracts were tested for their antioxidant activity and inhibition of xanthine oxidase. The results on the ferric reducing/antioxidant power assay (FRAP) and the 1,1-diphenyl-2-picryl-hydrazyl (DPPH) free radical scavenging assay showed that ethanolic and aqueous extracts possessed strong in vitro antioxidant capacity. Ethanolic extract had the highest phenol concentration. In vivo antioxidant activities of ethanolic and aqueous extracts on damaged mouse livers indicated that both extracts were effective against acute CCl4-induced hepatic.
Results on glucose-induced hyperglycemic mice treated with different doses of both extracts through oral delivery showed that ethanolic (at a dose of 40 mg/kg) and aqueous (at a dose of 50 mg/kg) extracts of
A. bracteosum exhibited inhibition percentages similar to the standard drug glibenclamide. The results obtained indicate that A. bracteosum is a potential antioxidant, anti-gout, hepato-protective and anti-hyperglycemic agent.