Study on the ability of melanin in treatment of hepatitis

Authors

  • Phan Thi Thu Trường Đại học Khoa học Tự nhiên, ĐH Quốc gia Hà Nội
  • Bui Thi Van Khanh Trường Đại học Khoa học Tự nhiên, ĐH Quốc gia Hà Nội
  • Do Minh Ha Trường Đại học Khoa học Tự nhiên, ĐH Quốc gia Hà Nội
  • Nguyen Dinh Thang Faculty of Biology, VNU University of Science

DOI:

https://doi.org/10.15625/2615-9023/v40n2se.13502

Keywords:

Anti-oxydant, CCl4, hepatic inflammation, malondialdehyde (MDA), melanin.

Abstract

In this study, the strong anti-oxidant melanin, isolated from squid ink-sac, was used to treat Swiss mice with chronic hepatitis caused by tetrachloro carbon (CCl4). Our results showed that melanin significantly reduced MDA concentration in liver and chemi-luminescent intensity in blood samples. Histological analysis also indicated that melanin could help necrotic mouse livers effectively recover to normal condition. Moreover, gene expression analysis showed increased transcription levels of SOD, GP-x, CAT and decreased transcription level of COX-2 in liver samples of mice with chronic hepatitis compared to those of control mice. In summary, results of this study suggested that melanin can be a potential candidate for treatment of oxidative stress and hepatic inflammation.

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Published

30-06-2018

How to Cite

Thu, P. T., Khanh, B. T. V., Ha, D. M., & Thang, N. D. (2018). Study on the ability of melanin in treatment of hepatitis. Academia Journal of Biology, 40(2se). https://doi.org/10.15625/2615-9023/v40n2se.13502

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