Hepatoprotective effects of ethyl acetate extracts of Polygonum tomentosum Willd. and Orthosiphon aristatus (Blume) Miq. against carbon tetrachloride induced chronic toxicity

Authors

  • Nguyen Ngoc Hong Ho Chi Minh city University of Technology
  • Huynh Ngoc Thuy University of Medicine and Pharmacy, Ho Chi Minh city

DOI:

https://doi.org/10.15625/0866-7160/v34n3se.1805

Keywords:

Orthosiphon aristatus, Polygonum tomentosum, ALT, CCl4, hepatoprotective effect, ethyl acetat extract

Abstract

Orthosiphon aristatus Blume. is a medicinal herb useful as a diuretic agent, used popularly in Vietnam and in the world. Polygonum tomentosum Willd. is a perennial herb growing in marshy areas, along ditches and field margins in Vietnam, but the efficacy of this herb in treatment of diseases remains unknown. The purpose of the present study was to examine the ethyl acetate extracts of O. aristatus and P. tomentosum against chronic carbon tetrachloride (CCl4) induced liver damage for 8 weeks. The hepatoprotective effects of these extracts were found comparable to that of silymarin, a hepatoprotective agent against hepatotoxicity of various chemicals. At the dose of 16 mg/kg, ethyl acetate extract of O. aristatus showed protective effect against CCl4 damage on liver with ALT activity was decreased 55% compared to toxic group, which was equivalently compared with silymarin at the same dose. Ethyl acetate extract of P. tomentosum reduced 65% ALT activity in serum of chronic CCl4 induced hepatotocity in mice, this result revealed that ethyl acetate extract of Polygonum tomentosum had a better hepatoprotective activity than silymarin at the dose of 16 mg/kg. The results of the present study indicate that P. tomentosum and O. aristatus are potential sources of natural hepatoprotection

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Published

06-08-2012

How to Cite

Hong, N. N., & Thuy, H. N. (2012). Hepatoprotective effects of ethyl acetate extracts of Polygonum tomentosum Willd. and Orthosiphon aristatus (Blume) Miq. against carbon tetrachloride induced chronic toxicity. Academia Journal of Biology, 34(3se), 313–318. https://doi.org/10.15625/0866-7160/v34n3se.1805

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