Bioactivity of some compounds isolated from the heartwood of Dalbergia oliveri Gamble ex Prain

Authors

  • Pham Thanh Loan Hung Vuong University, Phu Tho
  • Tran Huy Thai VAST
  • Phan Van Kiem VAST
  • Hoang Le Tuan Anh VAST
  • Chau Van Minh VAST
  • Do Thi Thao VAST
  • Tran Thi Suu

DOI:

https://doi.org/10.15625/0866-7160/v35n4.3772

Keywords:

Dalbergia oliveri, bioactivity, cytotoxic activity, antioxidative activity, anti-microbioactivity

Abstract

Several species of the genus Dalbergia have been used for a long time in Vietnam as traditional medicine, there was a few papers concerning biology and taxonomy of Dalbergia in Vietnam. In our study, first time ten bioactive compounds isolated from the heartwood of Dalbergia oliveri were evaluated. The results showed that from the cytotoxic assay, two compounds numbered as (9) (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan and numbered as (10) 3hydroxy-9 methoxyterocarpan exhibited strong cytotoxic activities with the IC50 values ranging from 3.76 mg/ml to 7.09 mg/ml. The compound numbered as (9) (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan also showed a mild antioxidative activity with the ED50 were 31.46 mg/ml. None of the ten tested compounds were evaluated for the anti-microbiological activity in vitro.

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Published

19-12-2013

How to Cite

Loan, P. T., Thai, T. H., Kiem, P. V., Tuan Anh, H. L., Minh, C. V., Thao, D. T., & Suu, T. T. (2013). Bioactivity of some compounds isolated from the heartwood of Dalbergia oliveri Gamble ex Prain. Academia Journal of Biology, 35(4), 439–444. https://doi.org/10.15625/0866-7160/v35n4.3772

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