Evaluation and application of Drosophila melanogaster model for anti-cancer herb screening

Authors

  • Vu Hoang Giang VAST
  • Cao Thi Thuy Trang
  • Nguyen Minh Can
  • Dang Ngoc Anh Suong
  • Dang Thi Phuong Thao

DOI:

https://doi.org/10.15625/0866-7160/v37n1se.6117

Keywords:

Drosophila melanogaster, Ehretia asperula, anti-cancer, transcription factor yorkie

Abstract

In this study, we evaluate Drosophila melanogaster model which over-express YorkieS168A protein in order to apply the model for anti-cancer herb screening. Transcriptional co-activator YorkieS168A (Yki) plays a role in organ size control and concerns some cancer diseases. In fly model, over-expression of YorkieS168A protein at eye tissue causes abnormal eye phenotype. As mass of cancerous cells, the abnormal eye phenotype is resulted by miss-control of cell proliferation as shown by anti PH3 signal after morphogenesis furrow. Interestingly, our results also show that ethanol 50% extraction of Ehretia asperula Zoll. & Mor. reduces abnormal eye phenotype in over-expressed YkiS168A flies. All the results show that over-expressed YkiS168A fly model serves as a potential model for anti-cancer herb screening.

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Published

25-04-2015

How to Cite

Giang, V. H., Thuy Trang, C. T., Can, N. M., Anh Suong, D. N., & Phuong Thao, D. T. (2015). Evaluation and application of Drosophila melanogaster model for anti-cancer herb screening. Academia Journal of Biology, 37(1se), 245–248. https://doi.org/10.15625/0866-7160/v37n1se.6117

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