Antibody-drug conjugates: Principles and clinical results in breast cancer treatment

Authors

  • Nguyen Phuong Loan
  • Duong Hong Quan Viện Nghiên cứu Tế bào Gốc và Công nghệ Gen Vinmec

DOI:

https://doi.org/10.15625/0866-7160/v39n4.9327

Keywords:

Antibody-drug conjugate, immunotherapy, monoclonal antibody, breast cancer

Abstract

Antibody-drug conjugates (ADCs) are consisted of the combination of highly specific monoclonal antibodies (mAbs) with conventional cytotoxic agents to particular cancer types. The use of mAbs that are specific to tumor cell-surface proteins allows highly selective accumulation of cytotoxic agents as ADCs at the tumor tissue, that is not achievable with conventional cytotoxic agents alone. Designing of effective ADCs for cancer treatment requires identification of an appropriate target, a mAb against the target, potent cytotoxic agents and conjugation of the mAb to cytotoxic agents. Until now, three ADCs including Gemtuzumab ozogamicin, Brentuximab and trastuzumab emtansine have received an FDA approval so far. These three ADCs have shown improved efficacy and safety data compared with standard chemotherapy for the treatment of patients of acute myeloid leukemia, advanced lymphoma and breast cancer, respectively. Moreover, several promising ADCs are now in the latter-phase of clinical testing. Thus, with special focusing on these new anti-cancer drugs, this review briefly describes the principles of ADCs including their structure and mechanism of action, and summarizes their clinical performance in breast cancer.

 

Citation: Nguyen Phuong Loan, Duong Hong Quan, 2017. Antibody-drug conjugates: Principles and clinical results in breast cancer treatment. Tap chi Sinh hoc, 39(4): 489-493. DOI: 10.15625/0866-7160/v39n4.9327.

*Corresponding author: quanvspt@gmail.com

Received 15 March 2017, accepted 12 December 2017

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Author Biography

Duong Hong Quan, Viện Nghiên cứu Tế bào Gốc và Công nghệ Gen Vinmec

Hóa sinh, Di truyền, Sinh học Phân tử, Sinh học Tế bào, Miễn dịch Phân tử, Ung thư

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Published

26-02-2018

How to Cite

Loan, N. P., & Quan, D. H. (2018). Antibody-drug conjugates: Principles and clinical results in breast cancer treatment. Academia Journal of Biology, 39(4), 490–495. https://doi.org/10.15625/0866-7160/v39n4.9327

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